Fig. 3. Transmembrane helix prediction using MemBrain [57] for a human C5a anaphylatoxin chemotactic receptor 1 (C5aR, a-d) and a hyperpolarization-activated cyclic nucleotide-gated ion channel (HCN-1, e-h). Structural overview of a) C5aR (pdb 5o9h[58]) and e) a HCN-1 subunit (pdb 5u6o[59]), b/f) Transmembrane Helix Propensity, c/g) predicted topology and d/h) sequence information about secondary structure and membrane regions taken from the corresponding pdb entries (www.rcsb.org [60]) extended with information about MemBrain predictions.